Angelman syndrome stems from a missing maternal UBE3A gene, but how it disrupts brain growth has remained unclear. Researchers at WashU Medicine discovered that accumulating asparagine synthetase tricks neurons into a perpetual emergency stress state, halting development. Blocking the enzyme restored normal brain growth in mice.
Angelman syndrome stems from a missing maternal UBE3A gene, but how it disrupts brain growth has remained unclear. Researchers at WashU Medicine discovered that accumulating asparagine synthetase tricks neurons into a perpetual emergency stress state, halting development. Blocking the enzyme restored normal brain growth in mice.
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